Product Description

CE104 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17531-50, ES17531-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains, two glycosylation sites, four cysteine-rich motifs, and two regions with homology to the glutamate receptor ionotropic, NMDA 1 protein. During ciliogenesis, the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium. Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips. Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome, which is characterized by a distinctive mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental delay, and ataxia. [provided by RefSeq, Feb 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CE104 AA range: 415-465

Isotype: IgG

Target: CE104

Specificity: This antibody detects endogenous levels of CE104 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 102kD

Function: Alternative Products: Additional isoforms may exist,Sequence Caution: Contaminating sequence. Potential poly-A sequence
Similarity: Contains 2 HEAT repeats

Subcellular Location: Cell projection, cilium Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole In interphase non-ciliated cells, localizes to the distal ends of both the mother and daughter centrioles In ciliated cells, present at the distal end of the daughter centriole, but not on the mother centriole, and at the tip of primary cilium Localization at the ciliary tip is also observed in motile cilia Throughout S phase, associated with both mother and daughter centrioles in each centrosome During metaphase and telophase, present at both spindle poles

Storage and Stability: -20°C/1 year

Gene Name: CEP104 KIAA0562

Protein Name: CE104

Mouse Gene ID: 230967

Mouse SwissProt Number: Q80V31

Research Use Only