Product Description

Choactase Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1975-50, ES1975-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CHAT, Choline O-acetyltransferase, CHOACTase, ChAT, Choline acetylase

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383

Isotype: IgG

Target: Choactase

Specificity: Choactase Polyclonal Antibody detects endogenous levels of Choactase protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Lymphocyte, Placenta, Spinal cord,

Observed Band (KD): 82,70kD

Fields: Glycerophospholipid metabolism, Cholinergic synapse

Function: Catalytic Activity: Acetyl-CoA + choline = CoA + O-acetylcholine
Disease: Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM: 254210], formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement
Function: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses
Online Information: Choline acetyltransferase entry,Similarity: Belongs to the carnitine/choline acetyltransferase family

Subcellular Location: nucleus, cytoplasm, cytosol, presynapse,

Storage and Stability: -20°C/1 year

Gene Name: CHAT

Protein Name: Choline O-acetyltransferase

Mouse SwissProt Number: Q03059

Rat SwissProt Number: P32738

Research Use Only