Product Description

Chr-A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1980-50, ES1980-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides, vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CHGA, Chromogranin-A, CgA, Pituitary secretory protein I, SP-I

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360

Isotype: IgG

Target: Chromogranin A

Specificity: Chr-A Polyclonal Antibody detects endogenous levels of Chr-A protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: GE-25 is found in the brain,

Observed Band (KD): 68kD

Function: Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas
Miscellaneous: Binds calcium with a low-affinity
PTM: Sulfated on tyrosine residues and/or contains sulfated glycans
Similarity: Belongs to the chromogranin/secretogranin protein family
Subcellular Location: Neuroendocrine and endocrine secretory granules

Subcellular Location: [Serpinin]: Secreted Cytoplasmic vesicle, secretory vesicle Pyroglutaminated serpinin localizes to secretory vesicle, Cytoplasmic vesicle, secretory vesicle Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle Secreted Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions In pituitary gonadotropes, located in large secretory granules

Storage and Stability: -20°C/1 year

Gene Name: CHGA

Protein Name: Chromogranin-A

Mouse Gene ID: 12652

Mouse SwissProt Number: P26339

Rat SwissProt Number: P10354

Research Use Only