Product Description

CHRNA7 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-12583-60, E-AB-12583-120, E-AB-12583-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CHRFAM7A

Target Synonym: 7nAChR; a7 nicotinic acetylcholine receptor; acetylcholine receptor; neuronal nicotinic; alpha-7 subunit; ACHA7; AChR; Acra7; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; alpha7; cholinergic receptor; neuronal nicotinic; alpha polypeptide 7; cholinergic receptor; nicotinic; alpha 7 (neuronal); cholinergic receptor; nicotinic; alpha 7; cholinergic receptor; nicotinic; alpha polypeptide 7; CHRNA7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein; alpha-7 chain; Neuronal acetylcholine receptor subunit alpha-7

Research Areas: Cancer, Metabolism, Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P36544

Background: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Concentration: 0.3 mg/mL

Immunogen: Synthetic peptide of human CHRFAM7A

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Calculated MW: 46kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only