Product Description

CHST2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1981-50, ES1981-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CHST2, GN6ST, Carbohydrate sulfotransferase 2, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2, GST-2, N-acetylglucosamine 6-O-sulfotransferase 1, GlcNAc6ST-1, Gn6ST-1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CHST2. AA range:1-50

Isotype: IgG

Target: CHST2

Specificity: CHST2 Polyclonal Antibody detects endogenous levels of CHST2 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed, Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta, Expressed by high endothelial cells (HEVs) and leukocytes,

Observed Band (KD): 58kD

Fields: Glycosaminoglycan biosynthesis - keratan sulfate

Function: Caution: It is uncertain whether Met-1 or Met-48 is the initiator
Function: Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains
Induction: Up-regulated upon cytokine activation
Online Information: GlycoGene database,Similarity: Belongs to the sulfotransferase 1 family.

Subcellular Location: Golgi apparatus, trans-Golgi network membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CHST2

Protein Name: Carbohydrate sulfotransferase 2

Mouse SwissProt Number: Q80WV3

Research Use Only