Product Description

CI072 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17460-50, ES17460-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CI072 AA range: 188-238

Isotype: IgG

Target: CI072

Specificity: This antibody detects endogenous levels of CI072 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Both isoforms are widely expressed, including kidney, lung, liver, heart, testis and several brain regions, such as cerebellum, Also expressed in the frontal cortex and in lymphoblasts (at protein level),

Molecular Weight (Da): 53kD

Fields: Autophagy - animal, Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases

Subcellular Location: Nucleus Cytoplasm Cytoplasm, P-body Cytoplasm, Stress granule Endosome Lysosome Cytoplasmic vesicle, autophagosome Secreted Cell projection, axon Cell projection, growth cone Perikaryon Detected in the cytoplasm of neurons from brain tissue (PubMed:21944778) Detected in the nucleus in fibroblasts (PubMed:21944779) During corticogenesis, transitions from being predominantly cytoplasmic to a more even nucleocytoplasmic distribution (By similarity), [Isoform 1]: Perikaryon Cell projection, dendrite Cell junction, synapse, presynapse Cell junction, synapse, postsynapse Expressed diffusely throughout the cytoplasm and dendritic processes of cerebellar Purkinje cells Also expressed diffusely throughout the cytoplasm of spinal motor neurons, [Isoform 2]: Nuc

Storage and Stability: -20°C/1 year

Gene Name: C9orf72

Protein Name: CI072

Mouse SwissProt Number: Q6DFW0

Rat Gene ID: 313155

Rat SwissProt Number: Q66HC3

Research Use Only