Product Description

CL12B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17409-50, ES17409-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CL12B AA range: 111-161

Isotype: IgG

Target: CL12B

Specificity: This antibody detects endogenous levels of CL12B at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis (PubMed:17562706), Expressed in melanocytes (at protein level) (PubMed:34310951),

Molecular Weight (Da): 30kD

Function: Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases
Function: Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases
Induction: Down-regulated in activated leukocytes recruited to a site of inflammation
PTM: Highly N-glycosylated. Glycosylation varies between cell types
Similarity: Contains 1 C-type lectin domain
Subcellular Location: Ligand binding leads to internalization
Subunit: Homodimer. Interacts with PTPN6 a

Subcellular Location: Cell membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CLEC12B UNQ5782/PRO16089

Protein Name: CL12B

Mouse Gene ID: 71183

Mouse SwissProt Number: Q149M0

Research Use Only