Product Description

CLC-6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1992-50, ES1992-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: chloride voltage-gated channel 6(CLCN6) Homo sapiens This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CLCN6, KIAA0046, Chloride transport protein 6, Chloride channel protein 6, ClC-6

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CLCN6. AA range:611-660

Isotype: IgG

Target: CLC-6

Specificity: CLC-6 Polyclonal Antibody detects endogenous levels of CLC-6 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Testis, ovary, small intestine, brain and skeletal muscle, Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells, Isoform 3 is only detected in kidney,

Observed Band (KD): 97kD

Function: Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter
Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters
PTM: N-glycosylated on several asparagine residues
Similarity: Belongs to the chloride channel (TC 2.A.49) family
Similarity: Contains 2 CBS domains
Subcellular Location: Detected in detergent-resistant lipid rafts
Tissue Specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney

Subcellular Location: Late endosome membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CLCN6

Protein Name: Chloride transport protein 6

Mouse Gene ID: 26372

Mouse SwissProt Number: O35454

Research Use Only