Product Description

CLC-KA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1995-50, ES1995-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CLCNKA, Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CLCNKA. AA range:581-630

Isotype: IgG

Target: CLC-KA

Specificity: CLC-KA Polyclonal Antibody detects endogenous levels of CLC-KA protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed predominantly in the kidney, All nephron segments expressing BSND also express CLCNK proteins,

Observed Band (KD): 75kD

Function: Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms
Similarity: Belongs to the chloride channel (TC 2.A.49) family
Similarity: Contains 2 CBS domains
Subunit: Interacts with BSND. Forms heteromers with BSND in the thin ascending limb of Henle
Tissue Specificity: Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proreins

Subcellular Location: Membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CLCNKA

Protein Name: Chloride channel protein ClC-Ka

Mouse SwissProt Number: Q9WUB7

Research Use Only