Cleaved-Caspase-3 p12 (D175) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA20689-50, RA20689-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: caspase 3 (CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, IF/ICC, IHC-p, ELISA Alternate Names: CASP3, CPP32, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1 Clonality: Polyclonal Dilution: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300 Molecular Weight: 20+35 Protein Molecular Weight (kDa): 20+35 Storage: -20°C/1 year Human Gene ID: 836 Human SwissProt Number: P42574 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only