Product Description

Cleaved-COL3A1 (G1221) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1035-50, ES1035-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: collagen type III alpha 1 chain(COL3A1) Homo sapiens This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: ELISA

Alternate Names: COL3A1, Collagen alpha-1(III) chain

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen III alpha1. AA range:1172-1221

Isotype: IgG

Target: Collagen III

Specificity: Cleaved-COL3A1 (G1221) Polyclonal Antibody detects endogenous levels of fragment of activated COL3A1 protein resulting from cleavage adjacent to G1221.

Dilution: ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Colon carcinoma, Liver, Placenta, Skin fibroblast,

Observed Band (KD): 95kD

Fields: Platelet activation, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Protein digestion and absorption, Amoebiasis, Diabetic cardiomyopathy

Function: Disease: Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type 3 (EDS3) [MIM: 130020], also known as benign hypermobility syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS3 is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity
Disease: Defects in COL3A1 are a cause of susceptibility to aortic aneurysm abdominal (AAA) [MIM: 100070]. AAA is a common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells
Disease: Defects in COL3A1 are the cause of Ehlers-Danlos syndrome t

Subcellular Location: Secreted, extracellular space, extracellular matrix

Storage and Stability: -20°C/1 year

Gene Name: COL3A1

Protein Name: Collagen alpha-1(III) chain

Mouse SwissProt Number: P08121

Research Use Only