Product Description

Cleaved-MMP-23 (Y79) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7054-50, BS7054-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Matrix metalloproteinases (MMPs) are highly homologous Zn2+ endopeptidases involved in extracellμlar matrix breakdown. MMP mediated extracellμlar remodeling occurs in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, including arthritis and metastasis. MMP-23 exhibits sequence similarity with most MMPs, but displays a difference in domain structure. The MMP-23 protein contains prepro-, catalytic, cysteine-rich, Interleukin-1 receptor-related and proline-rich domains. Lacking a recognizable signal sequence, MMP-23 has a short prodomain. In addition, MMP-23 contains a single cysteine residue that can be part of the cysteine-switch mechanism operation for maintaining enzyme latency. MMP-23 is a membrane-anchored glycoprotein with type II topology. Subcellμlar localization is predominantly perinuclear.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Matrix metalloproteinase-23, MMP 23, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22, Matrix metalloproteinase-23, soluble form, MMP23A, MMP21, MMP23B, MMP21, MMP22, MMP23

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Cleaved

Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human MMP-23.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cleaved-MMP-23 (Y79) polyclonal antibody detects endogenous levels of Cleaved-MMP-23 (37 kDa) protein.

Molecular Weight: ~ 37, 44 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O75900

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only