Product Description

CLIP-115 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1997-50, ES1997-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CLIP2, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4, CAP-Gly domain-containing linker protein 2, Cytoplasmic linker protein 115, CLIP-115, Cytoplasmic linker protein 2, Williams-Beuren syndrome chromosomal region 3 protein, Williams-Beuren syndro

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CLIP2. AA range:997-1046

Isotype: IgG

Target: CLIP-115

Specificity: CLIP-115 Polyclonal Antibody detects endogenous levels of CLIP-115 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Clones donated by Kazusa DNA Research Inst,, Epitheliu

Observed Band (KD): 120kD

Function: Disease: Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM: 194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23
Function: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of brain-specific organelle translocations
Similarity: Contains 2 CAP-Gly domains
Subcellular Location: Associated with the cytoskeleton
Subunit: Interacts with CLASP1 and CLASP2

Subcellular Location: Cytoplasm Cytoplasm, cytoskeleton Localizes preferentially to the ends of tyrosinated microtubules

Storage and Stability: -20°C/1 year

Gene Name: CLIP2

Protein Name: CAP-Gly domain-containing linker protein 2

Mouse Gene ID: 269713

Mouse SwissProt Number: Q9Z0H8

Rat Gene ID: 29264

Rat SwissProt Number: O55156

Research Use Only