Product Description

CLIP3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1999-50, ES1999-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CLIP3, CLIPR59, CAP-Gly domain-containing linker protein 3, Cytoplasmic linker protein 170-related 59 kDa protein, CLIP-170-related 59 kDa protein, CLIPR-59

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CLIP3. AA range:361-410

Isotype: IgG

Target: CLIP3

Specificity: CLIP3 Polyclonal Antibody detects endogenous levels of CLIP3 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Skin, Uterus,

Observed Band (KD): 60kD

Function: Domain: Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)
Function: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics
Miscellaneous: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required
Similarity: Contains 2 CAP-Gly domains
Similarity: Contains 3 ANK repeats
Subcellular Location: Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae
Subunit: Homodimer

Subcellular Location: Cell membrane, Lipid-anchor Cytoplasm Golgi apparatus, Golgi stack Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae

Storage and Stability: -20°C/1 year

Gene Name: CLIP3

Protein Name: CAP-Gly domain-containing linker protein 3

Mouse Gene ID: 76686

Mouse SwissProt Number: B9EHT4

Research Use Only