Product Description

CLK4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2003-50, ES2003-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CDC like kinase 4(CLK4) Homo sapiens The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CLK4, Dual specificity protein kinase CLK4, CDC-like kinase 4

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CLK4. AA range:101-150

Isotype: IgG

Target: CLK4

Specificity: CLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in liver, kidney, heart, muscle, brain and endothelial cells,

Observed Band (KD): 65kD

Fields: Legionellosis

Function: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein
Function: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU
PTM: Autophosphorylates on all three types of residues
Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily
Similarity: Contains 1 protein kinase domain
Subunit: Interacts with UBL5
Tissue Specificity: Expressed in liver, kidney, heart, muscle and brain

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: CLK4

Protein Name: Dual specificity protein kinase CLK4

Mouse Gene ID: 12750

Mouse SwissProt Number: O35493

Research Use Only