Product Description

CMIP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17366-50, ES17366-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CMIP AA range: 105-155

Isotype: IgG

Target: CMIP

Specificity: This antibody detects endogenous levels of CMIP at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.345% sodium azide.

Expression: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney, Lower expression in brain and liver, Expression is down-regulated in activated cells, Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver,

Observed Band (KD): 85kD

Function: Developmental Stage: Expressed in fetal liver
Disease: Isoform 2 expression is up-regulated in MCNS
Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor
Similarity: Contains 1 PH domain
Subcellular Location: Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients
Subunit: Interacts with FLNA
Tissue Specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Is

Subcellular Location: Nucleus Cytoplasm Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553) Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553) Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343)

Storage and Stability: -20°C/1 year

Gene Name: CMIP KIAA1694 TCMIP

Protein Name: CMIP

Mouse Gene ID: 74440

Mouse SwissProt Number: Q9D486

Research Use Only