Product Description

CMPK2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17365-50, ES17365-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CMPK2 AA range: 57-107

Isotype: IgG

Target: CMPK2

Specificity: This antibody detects endogenous levels of CMPK2 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Among all investigated tumors, leukemia cells show the most abundant expression,

Molecular Weight (Da): 49kD

Fields: Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism, Biosynthesis of cofactors

Function: Catalytic Activity: ATP + (d)CMP = ADP + (d)CDP
Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP, CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs
Similarity: Belongs to the thymidylate kinase family
Tissue Specificity: Among all investigated tumors, leukemia cells show the most abundant expression

Subcellular Location: Mitochondrion

Storage and Stability: -20°C/1 year

Gene Name: CMPK2

Protein Name: CMPK2

Mouse Gene ID: 22169

Mouse SwissProt Number: Q3U5Q7

Research Use Only