Product Description

CNOT6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17347-50, ES17347-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CNOT6 AA range: 293-343

Isotype: IgG

Target: CNOT6

Specificity: This antibody detects endogenous levels of CNOT6 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 61kD

Fields: RNA degradation

Function: Cofactor: Magnesium
Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex
Similarity: Belongs to the CCR4/nocturin family
Similarity: Contains 3 LRR (leucine-rich) repeats
Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Interacts with UNR

Subcellular Location: Cytoplasm Nucleus Predominantly cytoplasmic

Storage and Stability: -20°C/1 year

Gene Name: CNOT6 CCR4 KIAA1194

Protein Name: CNOT6

Mouse Gene ID: 104625

Mouse SwissProt Number: Q8K3P5

Rat Gene ID: 287249

Rat SwissProt Number: Q6AXU9

Research Use Only