Product Description

COG7 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17336-50, ES17336-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human COG7 AA range: 245-295

Isotype: IgG

Target: COG7

Specificity: This antibody detects endogenous levels of COG7 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.332% sodium azide.

Expression: Brain, Mammary gland, Synovial membrane,

Observed Band (KD): 85kD

Function: Disease: Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM: 608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions
Function: Required for normal Golgi function
Similarity: Belongs to the COG7 family
Subunit: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localiz

Subcellular Location: Golgi apparatus membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: COG7 UNQ3082/PRO10013

Protein Name: COG7

Mouse Gene ID: 233824

Mouse SwissProt Number: Q3UM29

Rat Gene ID: 293456

Rat SwissProt Number: Q3T1G7

Research Use Only