Product Description

Collagen IV α2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20798-50, RA20798-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: domain:Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain., function:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth., PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains., PTM:The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met residues., PTM:Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens., similarity:Belongs to the type IV collagen family., similarity:Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain., subunit:There are six type IV collagen isoforms, alpha 1 (IV)-alpha 6 (IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Collagen alpha-2 (IV) chain [Cleaved into: Canstatin]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 160 190

Protein Molecular Weight (kDa): 160 190

Storage: -20°C/1 year

Human Gene ID: 1284

Human SwissProt Number: P08572

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only