Product Description

COMP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17302-50, ES17302-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human COMP AA range: 628-678

Isotype: IgG

Target: COMP

Specificity: This antibody detects endogenous levels of COMP at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels, Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect,

Molecular Weight (Da): 83kD

Fields: Phagosome, PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Malaria, Human papillomavirus infection

Function: Disease: Defects in COMP are the cause of multiple epiphyseal dysplasia type 1 (EDM1) [MIM: 132400]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types
Disease: Defects in COMP are the cause of pseudoachondroplasia (PSACH) [MIM: 177170]. PSAC is a dominantly inherited chondrodysplasia characterized by short stature and early-onset osteoarthrosis. PSACH is more severe than EDM1 and is recognized in early childhood
Similarity: Belongs to the thrombospondin family
Similarity: Contains 1 TSP C-terminal (TSPC) domain
Similarity: Contains 4 EGF-like domains
Similarity: Contains 8 TSP type-3 repeats
Subunit: Pentamer, disulfide-linked

Subcellular Location: Secreted, extracellular space, extracellular matrix

Storage and Stability: -20°C/1 year

Gene Name: COMP

Protein Name: COMP

Mouse Gene ID: 12845

Mouse SwissProt Number: Q9R0G6

Rat Gene ID: 25304

Rat SwissProt Number: P35444

Research Use Only