Cortactin (Acetyl Lys235) Polyclonal Antibody - BT-AP02136

Cortactin (Acetyl Lys235) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02136-20, BT-AP02136-50, BT-AP02136-100

Citations, Manuals and MSDS Available upon request.

Background: CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. Cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. The aberrant regulation of CTTN contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for CTTN.

Research Areas: Signal Transduction

Target Protein: CTTN

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Cortactin (Acetyl Lys235) Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 61636

UniProt Accession: Human: Q14247; Mouse: Q60598

Synonyms: CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

GeneID: Human: 2017; Mouse: 13043

Research Use Only