Product Description

Corticotropin-releasing factor receptor 2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8600-50, ES8600-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)

Clonality: Polyclonal

Immunogen: Synthetic peptide from human protein at AA range: 221-295

Isotype: IgG

Target: CRF-RII

Specificity: The antibody detects endogenous Corticotropin-releasing factor receptor 2

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Amygdala, Brain, Skeletal muscle,

Observed Band (KD): 48kD

Fields: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Cushing syndrome

Function: Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Similarity: Belongs to the G-protein coupled receptor 2 family

Subcellular Location: Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CRHR2 CRF2R CRH2R

Protein Name: Corticotropin-releasing factor receptor 2

Mouse SwissProt Number: Q60748

Rat SwissProt Number: P47866

Research Use Only