Product Description

COTL1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17297-50, ES17297-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human COTL1 AA range: 29-79

Isotype: IgG

Target: COTL1

Specificity: This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas,

Molecular Weight (Da): 16kD

Function: Function: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization
Similarity: Belongs to the actin-binding proteins ADF family. Coactosin subfamily
Similarity: Contains 1 ADF-H domain
Subunit: Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner
Tissue Specificity: Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas

Subcellular Location: Cytoplasm Cytoplasm, cytoskeleton Nucleus

Storage and Stability: -20°C/1 year

Gene Name: COTL1 CLP

Protein Name: COTL1

Mouse Gene ID: 72042

Mouse SwissProt Number: Q9CQI6

Rat Gene ID: 361422

Rat SwissProt Number: B0BNA5

Research Use Only