Product Description

CP4AB Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17261-50, ES17261-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cytochrome P450 family 4 subfamily A member 11(CYP4A11) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CP4AB AA range: 389-439

Isotype: IgG

Target: CP4AB

Specificity: This antibody detects endogenous levels of CP4AB at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in liver (PubMed:7679927), Expressed in S2 and S3 segments of proximal tubules in cortex and outer medulla of kidney (PubMed:7679927, PubMed:10660572),

Molecular Weight (Da): 57kD

Function: Catalytic Activity: Octane + reduced rubredoxin + O(2) = 1-octanol + oxidized rubredoxin + H(2)O
Cofactor: Heme group
Function: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE)
Online Information: CYP4A11 alleles,polymorphism: CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid
Similarity: Belongs to the cytochrome P450 family
Tissue Specificity: Kidney and liver

Subcellular Location: Endoplasmic reticulum membrane, Peripheral membrane protein Microsome membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CYP4A11 CYP4A2

Protein Name: CP4AB

Research Use Only