Product Description

CSTN2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17198-50, ES17198-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CSTN2 AA range: 494-544

Isotype: IgG

Target: CSTN2

Specificity: This antibody detects endogenous levels of CSTN2 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.235% sodium azide.

Expression: Restricted to the brain,

Observed Band (KD): 105kD

Function: Domain: Binds synaptic Ca(2+) with its cytoplasmic domain
Function: May modulate calcium-mediated postsynaptic signals
PTM: Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1
Similarity: Contains 2 cadherin domains
Subcellular Location: Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization
Tissue Specificity: Restricted to the bra

Subcellular Location: Cell membrane, Single-pass type I membrane protein Endoplasmic reticulum membrane Golgi apparatus membrane Cell junction, synapse, postsynapse Cell projection, dendrite Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization

Storage and Stability: -20°C/1 year

Gene Name: CLSTN2 CS2

Protein Name: CSTN2

Mouse Gene ID: 64085

Mouse SwissProt Number: Q9ER65

Rat Gene ID: 171394

Rat SwissProt Number: Q8VDA1

Research Use Only