Product Description

Cyclin A Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20835-50, RA20835-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cyclin A1 (CCNA1) Homo sapiens The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multi

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, IHC-p, IF/ICC, ELISA

Alternate Names: CCNA1, Cyclin-A1, CCNA2, CCN1, CCNA, Cyclin-A2, Cyclin-A

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 53

Protein Molecular Weight (kDa): 53

Storage: -20°C/1 year

Human Gene ID: 8900/890

Human SwissProt Number: P78396/P20248

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only