Product Description

Cytokeratin 14/17 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8537-50, ES8537-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: KRT14

Clonality: Polyclonal

Immunogen: Synthetic peptide from human protein at AA range: 261-310

Isotype: IgG

Target: Cytokeratin 14/17

Specificity: The antibody detects endogenous Cytokeratin 14/17 protein

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the corneal epithelium (at protein level) (PubMed:26758872), Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum, Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair (PubMed:9457912), Found in keratinocytes surrounding the club hair during telogen (PubMed:9457912),

Observed Band (KD): 52kD

Fields: Estrogen signaling pathway, Staphylococcus aureus infection

Function: Disease: Defects in KRT14 are a cause of epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) [MIM: 131760]. DM-EBS is a severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement
Disease: Defects in KRT14 are a cause of epidermolysis bullosa simplex Koebner type (K-EBS) [MIM: 131900]. K-EBS is a form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, althought it is less severe
Disease: Defects in KRT14 are a cause of epidermolysis bullosa simplex Weber-Cockayne type (WC-EBS) [MIM: 131800]. WC-EBS is a form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin
Disease: Defects in KRT14 are the cause of derma

Subcellular Location: Cytoplasm Nucleus Expressed in both as a filamentous pattern

Storage and Stability: -20°C/1 year

Gene Name: KRT14/17

Protein Name: keratin 14, keratin 17

Research Use Only