Cytokeratin 6 Monoclonal Antibody (4A1) - BT-MCA0030

Cytokeratin 6 Monoclonal Antibody (4A1)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0030-20, BT-MCA0030-50, BT-MCA0030-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified| the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathoge

Research Areas: Signal transduction; Tags and; cell markers

Target Protein: KRT6A/B/C

Applications: WB, IHC-p, IF, ICC

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Keratin type II cytoskeletal 6A

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 60026

UniProt Accession: Human: P02538; P04259; P48668

Synonyms: Keratin type II cytoskeletal 6A; Keratin type II cytoskeletal 6B; Keratin type II cytoskeletal 6C

GeneID: Human: 3854; 286887; 3853

Research Use Only