Product Description

DAB2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17027-50, ES17027-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human DAB2 AA range: 683-733

Isotype: IgG

Target: DAB2

Specificity: This antibody detects endogenous levels of DAB2 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% sodium azide.

Expression: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary, Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine, Expressed in kidney proximal tubular epithelial cells (at protein level),

Observed Band (KD): 85kD

Fields: Endocytosis

Function: Function: Component of the CSF-1 signal transduction pathway
Similarity: Contains 1 PID domain
Subcellular Location: Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles
Subunit: Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN
Tissue Specificity: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine

Subcellular Location: Cytoplasm Cytoplasmic vesicle, clathrin-coated vesicle membrane Membrane, clathrin-coated pit Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles During mitosis is progressively displaced from the membrane and translocated to the cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: DAB2 DOC2

Protein Name: DAB2

Mouse Gene ID: 13132

Mouse SwissProt Number: P98078

Rat Gene ID: 79128

Rat SwissProt Number: O88797

Research Use Only