Product Description

DCK Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16994-50, ES16994-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human DCK AA range: 62-112

Isotype: IgG

Target: DCK

Specificity: This antibody detects endogenous levels of DCK at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 29kD

Fields: Purine metabolism, Pyrimidine metabolism, Metabolic pathways, Nucleotide metabolism

Function: Catalytic Activity: NTP + deoxycytidine = NDP + dCMP
Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the DCK/DGK family
Subunit: Homodimer

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: DCK

Protein Name: DCK

Mouse Gene ID: 13178

Mouse SwissProt Number: P43346

Rat Gene ID: 79127

Rat SwissProt Number: P48769

Research Use Only