Product Description

DEN1B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16970-50, ES16970-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2, see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human DEN1B AA range: 325-375

Isotype: IgG

Target: DEN1B

Specificity: This antibody detects endogenous levels of DEN1B at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary, Significantly up-regulated in effector memory T-cells as compared with naive T-cells,

Molecular Weight (Da): 47kD

Function: PTM: Isoform 5 is phosphorylated on Tyr-475 and Tyr-484
Similarity: Contains 1 dDENN domain
Similarity: Contains 1 DENN domain
Similarity: Contains 1 uDENN domain

Subcellular Location: Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle

Storage and Stability: -20°C/1 year

Gene Name: DENND1B C1orf218 FAM31B

Protein Name: DEN1B

Mouse Gene ID: 329260

Mouse SwissProt Number: Q3U1T9

Research Use Only