DNA pol δ3 rabbit pAb - ES4537

DNA pol δ3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4537-50, ES4537-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012],

Alternate Name: POLD3; KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human POLD3. AA range:411-460

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 51kD

Human Gene ID: 10714

Human SWISS Prot NO: Q15054

Subcellular Location: Cytoplasm. Nucleus. Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739). Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543).

Research Use Only