Product Description

DnaseⅠPolyclonal Antibody

Sizes: 50μL, 100μL, 200μL

Catalogue Numbers: E-AB-40592-50, E-AB-40592-100, E-AB-40592-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DnaseⅠ

Target Synonym: Deoxyribonuclease-1; DNASE1; DNL1; DRNI

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P24855

Background: Deoxyribonuclease I (DNase I) is an endonuclease which is secreted to cleave DNA in the extracellular space down to an average of tetranucleotides with 5′ monophosphate and 3′ hydroxyl DNA ends . Both single-stranded DNA and double-stranded DNA are degraded by Dnase I. This nuclease appears to account for the major nucleolytic activity on DNA in serum and is responsible for the degradation of the majority of circulating DNA derived from apoptotic and necrotic cell death and from neutrophil extracellular traps. In addition to its role in the serum, it has been proposed as one of the deoxyribonucleases responsible for DNA fragmentation in the process of apoptosis.

Concentration: 0.7mg/mL

Immunogen: Recombinant Human DnaseⅠ protein expressed by E.coli.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Purification Method: Antigen Affinity Purification

Dilution: WB: 1:1000-2000

Calculated MW: 31kDa

Observed MW: 31kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only