Dnmt3b Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA20595-50, RA20595-100
Citations, Manuals and MSDS Available upon request.
Background: DNA methyltransferase 3 beta (DNMT3B) Homo sapiens CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Alternative Names: DNMT3B; DNA (cytosine-5) -methyltransferase 3B; Dnmt3b; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; M.HsaIIIB
Applications: WB; IHC-p; IF/ICC; ELISA
Species Cross-Reactivity: Human; Chicken (testedbyourcustomer)
GeneID (Human): 1789
Protein MW (KDa): 96
SWISS: Q9UBC3
Source: Rabbit
Research Use Only