Product Description

DREB Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16896-50, ES16896-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human DREB AA range: 484-534

Isotype: IgG

Target: DREB

Specificity: This antibody detects endogenous levels of DREB at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578), Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578), Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578), Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400), Expressed in the brain (PubMed:8216329, Ref,2), Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref,2),

Molecular Weight (Da): 71kD

Function: Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively
Similarity: Contains 1 ADF-H domain
Subunit: Binds F-actin
Tissue Specificity: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas

Subcellular Location: Cytoplasm Cell projection, dendrite Cytoplasm, cell cortex Cell junction Cell projection, growth cone In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400) In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: DBN1 D0S117E

Protein Name: DREB

Mouse Gene ID: 56320

Mouse SwissProt Number: Q9QXS6

Rat Gene ID: 81653

Rat SwissProt Number: Q07266

Research Use Only