Product Description

DTX3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16883-50, ES16883-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human DTX3 AA range: 87-137

Isotype: IgG

Target: DTX3

Specificity: This antibody detects endogenous levels of DTX3 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 38kD

Fields: Notch signaling pathway

Function: Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity
Sequence Caution: Intron retention
Similarity: Belongs to the Deltex family
Similarity: Contains 1 RING-type zinc finger
Subunit: Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: DTX3 RNF154

Protein Name: DTX3

Mouse Gene ID: 80904

Mouse SwissProt Number: Q80V91

Research Use Only