Product Description

DUSP6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20772-50, ES20772-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: DUSP6, MKP3, PYST1, Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3

Clonality: Polyclonal

Immunogen: Synthetic Peptide of DUSP6

Isotype: IgG

Target: DUSP6

Specificity: DUSP6 Rabbit Polyclonal detects endogenous levels of DUSP6

Dilution: WB 1:1000-3000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in keratinocytes (at protein level),

Observed Band (KD): 42,44kD

Fields: MAPK signaling pathway, Transcriptional misregulation in cancer, Acute myeloid leukemia

Function: Catalytic Activity: A phosphoprotein + H(2)O = a protein + phosphate
Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Function: Inactivates MAP kinases. Has a specificity for the ERK family
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 rhodanese domain
Similarity: Contains 1 tyrosine-protein phosphatase domain

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: DUSP6

Protein Name: Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)

Mouse SwissProt Number: Q9DBB1

Rat SwissProt Number: Q64346

Research Use Only