Product Description

EphA3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES5125-50, ES5125-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: EPHA3, ETK, ETK1, HEK, TYRO4, Ephrin type-A receptor 3, EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from EphA3. at AA range: 540-620

Isotype: IgG

Target: EphA3

Specificity: EphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed, Highest level in placenta,

Observed Band (KD): 100kD

Fields: Axon guidance

Function: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Disease: Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM: 114500]
Function: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
Similarity: Contains 1 protein kinase domain
Similarity: Contains 1 SAM (sterile alpha motif) domain
Similarity: Contains 2 fibronectin type-III domains
Tissue Specificity: Widely expressed. Highest level in placenta

Subcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: EPHA3

Protein Name: Ephrin type-A receptor 3

Mouse SwissProt Number: P29319

Rat Gene ID: 29210

Rat SwissProt Number: O08680

Research Use Only