Product Description

EST3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16669-50, ES16669-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Alternate Names: Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human EST3 AA range: 447-497

Isotype: IgG

Target: EST3

Specificity: This antibody detects endogenous levels of EST3 at Human

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.193% sodium azide.

Expression: Expressed in liver, colon and small intestine,

Observed Band (KD): 65kD

Function: Catalytic Activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics
PTM: N-glycosylated
Similarity: Belongs to the type-B carboxylesterase/lipase family
Tissue Specificity: Expressed in liver, colon and small intestine

Subcellular Location: Endoplasmic reticulum lumen

Storage and Stability: -20°C/1 year

Gene Name: CES3 UNQ869/PRO1887

Protein Name: EST3

Research Use Only