Product Description

FAIM3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16536-50, ES16536-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324], Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human FAIM3 AA range: 123-173

Isotype: IgG

Target: FAIM3

Specificity: This antibody detects endogenous levels of FAIM3 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys, Very weak expression detected in spleen, liver, heart, and salivary gland, Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11, 19 and Reh, No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa, Detected at high levels in chronic lymphocytic leukemia cells,

Molecular Weight (Da): 43kD

Function: Domain: The Ig-like domain is required for the anti-apoptotic ability
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation
Induction: By T-cell activation
Miscellaneous: 'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
Tissue Specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in l

Subcellular Location: [Isoform 1]: Membrane, Single-pass membrane protein, [Isoform 3]: Secreted Detected in the serum

Storage and Stability: -20°C/1 year

Gene Name: FAIM3 TOSO

Protein Name: FAIM3

Mouse Gene ID: 69169

Mouse SwissProt Number: A1KXC4

Rat Gene ID: 548326

Rat SwissProt Number: Q5M871

Research Use Only