Product Description

FAN Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16527-50, ES16527-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human FAN AA range: 147-197

Isotype: IgG

Target: FAN

Specificity: This antibody detects endogenous levels of FAN at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Molecular Weight (Da): 101kD

Fields: Sphingolipid signaling pathway

Function: Function: Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE
Similarity: Contains 1 BEACH domain
Similarity: Contains 1 GRAM domain
Similarity: Contains 6 WD repeats
Tissue Specificity: Ubiquitous

Subcellular Location: cytoplasm, cytosol, endomembrane system, extrinsic component of membrane,

Storage and Stability: -20°C/1 year

Gene Name: NSMAF FAN

Protein Name: FAN

Mouse Gene ID: 18201

Mouse SwissProt Number: O35242

Research Use Only