Product Description

FGFR4 (phospho-Y642) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64391-50, BS64391-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of mμltifunctional polypeptide growth factors that stimμlate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellμlar ligandbinding region containing three immunoglobμlin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-4, unlike the other FGFR genes, is alternatively spliced to produce only one isoform. It is expressed in fetal adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues. FGFR-4 is also overexpressed in breast cancers and, subsequently, is a potential target for drug therapy.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Fibroblast growth factor receptor 4 , FGFR-4, CD334, FGFR4, JTK2, TKF

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human FGFR4 around the phosphorylation site of Tyrosine642.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: FGFR4 (phospho-Y642) polyclonal antibody detects endogenous levels of FGFR4 protein only when phosphorylated at Try642 .

Molecular Weight: ~ 100 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22455

Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Research Use Only