FITC Rabbit anti-Human TCR γ/δ Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A28422-100, A28422-200, A28422-500
Citations, Manuals and MSDS Available upon request.
Background: The γδ T-cell receptor (TCR) is a heterodimer composed of γ and δ chains, expressed on the T-cell surface and involved in antigen recognition. The engagement of the γδ TCR with antigen triggers the phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3 chains. Unlike αβ T cells, human γδ T cells recognize and kill transformed cells in a manner unrestricted by human leukocyte antigen (HLA) presentation. γδ T lymphocytes primarily develop in the thymus, where their defining receptor is generated through RAG-mediated recombination of a relatively limited repertoire of variable (V), diversity (D), and joining (J) gene segments. In addition to the T-cell receptor, γδ T cells often express activating natural killer (NK) receptors, which bind to stress-induced surface molecules frequently expressed on malignant cells.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 6964/6965 Alternate Names: TCRD; TRD@; TCRDV1; TCRG; TRG@
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Adaptive Immunity, Immunology
NCBI Alias: TCR γ/δ
Modifications: Unmodified
Conjugate: FITC. Ex:491nm. Em:516nm.
Clone Number Info: ARC79216
Research Use Only