Product Description

FRPD2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16319-50, ES16319-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human FRPD2 AA range: 1161-1211

Isotype: IgG

Target: FRPD2

Specificity: This antibody detects endogenous levels of FRPD2 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in epithelial cells,

Molecular Weight (Da): 144kD

Function: Caution: Could be the product of a pseudogene. This is the product of related genes or pseudogenes located in a region of chromosome 10q which contains a segmental duplication resulting in three nearly identical regions
Similarity: Contains 1 FERM domain
Similarity: Contains 1 KIND domain
Similarity: Contains 1 PDZ (DHR) domain
Similarity: Contains 2 PDZ (DHR) domains
Similarity: Contains 3 PDZ (DHR) domains

Subcellular Location: Cytoplasm Basolateral cell membrane Cell junction, tight junction Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane Colocalizes with TJP1 at tight junctions Its recruitment to cell-cell contacts requires CDH1

Storage and Stability: -20°C/1 year

Gene Name: FRMPD2 PDZD5C PDZK4 PDZK5C

Protein Name: FRPD2

Research Use Only