Product Description

GALT2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES16271-50, ES16271-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human GALT2 AA range: 30-80

Isotype: IgG

Target: GALT2

Specificity: This antibody detects endogenous levels of GALT2 at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.194% sodium azide.

Expression: Widely expressed,

Observed Band (KD): 65kD

Fields: Mucin type O-glycan biosynthesis, Other types of O-glycan biosynthesis, Metabolic pathways

Function: Catalytic Activity: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide
Cofactor: Calcium
Cofactor: Manganese
Domain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity
Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked

Subcellular Location: Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein Secreted Resides preferentially in the trans and medial parts of the Golgi stack A secreted form also exists

Storage and Stability: -20°C/1 year

Gene Name: GALNT2

Protein Name: GALT2

Mouse Gene ID: 108148

Mouse SwissProt Number: Q6PB93

Research Use Only