Product Description

GDF-5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4032-50, ES4032-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: GDF5, CDMP1, Growth/differentiation factor 5, GDF-5, Cartilage-derived morphogenetic protein 1, CDMP-1, Radotermin

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5. AA range:361-410

Isotype: IgG

Target: GDF-5

Specificity: GDF-5 Polyclonal Antibody detects endogenous levels of GDF-5 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Predominantly expressed in long bones during embryonic development, Expressed in monocytes (at protein level),

Observed Band (KD): 55kD

Fields: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway

Function: Disease: Defects in GDF5 are a cause of brachydactyly type A2 (BDA2) [MIM: 112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits
Disease: Defects in GDF5 are a cause of symphalangism proximal syndrome (SYM1) [MIM: 185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities,

Subcellular Location: Secreted Cell membrane

Storage and Stability: -20°C/1 year

Gene Name: GDF5

Protein Name: Growth/differentiation factor 5

Mouse Gene ID: 14563

Mouse SwissProt Number: P43027

Research Use Only