Product Description

GDI-2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4047-50, ES4047-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: GDI2, RABGDIB, Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from the C-terminal region of human GDI-2.

Isotype: IgG

Target: GDI-2

Specificity: GDI-2 Polyclonal Antibody detects endogenous levels of GDI-2 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Observed Band (KD): 50kD

Function: Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them
Similarity: Belongs to the Rab GDI family
Tissue Specificity: Ubiquitous

Subcellular Location: Cytoplasm Membrane, Peripheral membrane protein

Storage and Stability: -20°C/1 year

Gene Name: GDI2

Protein Name: Rab GDP dissociation inhibitor beta

Mouse Gene ID: 14569

Mouse SwissProt Number: Q61598

Rat Gene ID: 29662

Rat SwissProt Number: P50399

Research Use Only