Product Description

GFRα-4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES7148-50, ES7148-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: GFRA4, GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190

Isotype: IgG

Target: GFRα-4

Specificity: GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Predominantly expressed in the adult thyroid gland, Low levels also found in fetal adrenal and thyroid glands,

Observed Band (KD): 30kD

Function: Alternative Products: Additional isoforms seem to exist,Function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla
Similarity: Belongs to the GDNFR family
Tissue Specificity: Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands

Subcellular Location: [Isoform GFRalpha4a]: Cell membrane, Lipid-anchor, GPI-anchor, [Isoform GFRalpha4b]: Cell membrane, Lipid-anchor, GPI-anchor, [Isoform GFRalpha4c]: Secreted

Storage and Stability: -20°C/1 year

Gene Name: GFRA4

Protein Name: GDNF family receptor alpha-4

Mouse SwissProt Number: Q9JJT2

Research Use Only