Product Description

GLμl Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BZ00935-50, BZ00935-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Glutamine synthetase (GI Syn) forms a homooctamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IP, FC

Alternate Names: Glutamine synthetase, GS, Glutamate decarboxylase, Glutamate--ammonia ligase, GLNS, Gl Syn

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthesized peptide derived from human Glutamine Synthetase.

Dilution: WB: 1:500-1:2000
IHC: 1:50-1:200
IP/FC: 1:50

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Glutamine Synthetase Antibody detects endogenous levels of total Glutamine Synthetase.

Molecular Weight: ~ 49 kDa

Pathway: Glutamine Metabolism,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P15104

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only